OR2Z1

Across TCGA patient cohorts, OR2Z1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2Z1-associated genes across cancer lineages are Myosin-IIa_pS1943, MSH2, and SETD2. Each is linked with OR2Z1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2Z1-to-partner and partner-to-OR2Z1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by OR2Z1-low versus OR2Z1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2Z1→partner) and Y-score (partner→OR2Z1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.272	+3.335	.012	.005	3	2
UCEC	MSH2 →	-0.415	-2.973	<.001	.035	3	1
UCEC	SETD2 →	-0.253	-3.321	.026	.010	3	1
UCEC	Axl →	+0.222	+2.818	.041	.035	3	1
SKCM	Smac →	+0.312	+2.472	.002	.010	3	1
SKCM	cIAP →	+0.148	+3.169	.008	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Myosin-IIa_pS1943 by OR2Z1 expression — UCEC

Explore this box plot interactively →