OR2W3

Across TCGA pan-cancer cohorts, OR2W3 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated OR2W3 data layer compared with 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher OR2W3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR2W3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UVM show a favorable association.

LUSC, UCEC, and LUAD are the cancer types where OR2W3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Quartile	All	0.241	0.464	<.001	94	view →
UCEC	OS	Tertile	All	0.495	0.734	<.001	74	view →
LUAD	DFS	Tertile	IV	0.389	0.884	.002	58	view →
COAD	DFS	Tertile	III,IV	0.339	0.650	<.001	37	view →
BRCA	DFS	Median	III,IV	0.933	0.820	<.001	35	view →
UVM	DFS	Median	II,III,IV	0.872	0.616	.013	25	view →
STAD	OS	Median	All	0.520	0.633	.014	18	view →
MESO	OS	Tertile	III,IV	0.641	0.162	.026	18	view →
CESC	DFS	Tertile	IV	0.745	0.359	.020	18	view →
HNSC	OS	Tertile	II,III,IV	0.580	0.700	.016	18	view →
BLCA	DFS	Median	All	0.235	0.457	.028	10	view →
OV	OS	Tertile	IV	0.463	0.705	.018	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

OR2W3–LUSC (OS)

Open the LUSC breakdown →