OR2W3

Across TCGA pan-cancer cohorts, OR2W3 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OR2W3 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher OR2W3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OR2W3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and GBM show a favorable association.

ESCA, LIHC, and SKCM are the cancer types where OR2W3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.108	0.703	<.001	36	view →
LIHC	OS	Median	All	0.092	0.783	<.001	27	view →
SKCM	DFS	Median	III,IV	0.878	0.561	.007	12	view →
STAD	OS	Median	II,III,IV	0.224	0.710	.009	9	view →
GBM	DFS	Median	All	1.000	0.204	.042	3	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OR2W3–ESCA (OS)

Open the ESCA breakdown →