OR2V2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, OR2V2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2V2-associated genes across cancer lineages are PKC-delta_pS664, EGFR_pY1068, and p38-MAPK_pT180_Y182. Each is linked with OR2V2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR2V2-to-partner and partner-to-OR2V2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2V2→partner) and Y-score (partner→OR2V2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPKC-delta_pS664 →-0.102-2.999.045.03533
UCECEGFR_pY1068 →-0.222-1.700.037.04432
UCECp38-MAPK_pT180_Y182 →-0.466-1.687.014.04432
UCECRad50 →-0.235-2.906.022.00132
UCECSTAT3_pY705 →-0.434-2.797<.001.00332
UCECTFRC →+0.603+2.321.007.03432
Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

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