OR2T34

Across TCGA patient cohorts, OR2T34 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR2T34-associated genes across cancer lineages are Cyclin-B1, FoxM1, and ASNS. Each is linked with OR2T34 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR2T34-to-partner and partner-to-OR2T34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by OR2T34-low versus OR2T34-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T34→partner) and Y-score (partner→OR2T34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.385	+2.128	.013	.009	3	3
LUSC	FoxM1 →	+0.249	+2.825	.036	.033	3	2
LUAD	ASNS →	+0.540	+3.000	.035	.036	3	1
LUSC	N-Ras →	-0.101	-3.308	.013	.009	3	1
LUSC	Chk1_pS345 →	+0.115	+3.197	.004	.009	3	1
UCEC	c-Met_pY1235 →	+0.095	+2.817	.037	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Cyclin-B1 by OR2T34 expression — SKCM

Explore this box plot interactively →