OR2T11

Across TCGA cell cohorts, OR2T11 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR2T11-associated genes across cancer lineages are CLEC6A, ITGAD, and PRAMEF20. Each is linked with OR2T11 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2T11-to-partner and partner-to-OR2T11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC6A grouped by OR2T11-low versus OR2T11-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T11→partner) and Y-score (partner→OR2T11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CLEC6A →	+0.126	+5.029	<.001	.006	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	SFTPB →	+0.307	+3.548	<.001	.004	2	1
LARGE_INTESTINE	PTTG2 →	+0.080	+3.497	.002	.004	2	1
BLOOD_Lymphoma	ABCB11 →	+0.107	+4.247	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CLEC6A by OR2T11 expression — LUNG_SCLC

Explore this box plot interactively →