Across TCGA pan-cancer cohorts, OR2T10 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OR2T10’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where OR2T10 RNA is repressed in tumor relative to normal tissue. In most cancer types OR2T10 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.
KIRP, KICH, and UCEC are the cancer types where OR2T10 tumor–normal differential expression is most reproducible.