OR2T1

Across TCGA patient cohorts, OR2T1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible OR2T1-associated genes across cancer lineages are 4E-BP1, PCNA, and Cyclin-B1. Each is linked with OR2T1 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR2T1-to-partner and partner-to-OR2T1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by OR2T1-low versus OR2T1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T1→partner) and Y-score (partner→OR2T1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1 →	+0.429	+2.820	.003	.035	3	4
UCEC	PCNA →	+0.310	+3.584	<.001	.002	3	3
UCEC	Cyclin-B1 →	+0.556	+1.906	.013	.016	2	4
LUSC	JNK2 →	-0.170	-2.672	.039	.006	2	3
LUSC	NF-kB-p65_pS536 →	-0.323	-1.990	.039	.031	3	2
LUSC	eEF2K →	-0.453	-3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

4E-BP1 by OR2T1 expression — LUAD

Explore this box plot interactively →