OR2L8

Across TCGA patient cohorts, OR2L8 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible OR2L8-associated genes across cancer lineages are OR10A7, SULT1C3, and PNMA5. Each is linked with OR2L8 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2L8-to-partner and partner-to-OR2L8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A7 grouped by OR2L8-low versus OR2L8-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2L8→partner) and Y-score (partner→OR2L8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	OR10A7 →	+0.060	+4.039	<.001	.009	3	1
SCLC	SULT1C3 →	+0.257	+4.774	<.001	<.001	3	1
SCLC	PNMA5 →	+1.927	+4.047	.002	.004	3	1
SCLC	OR10R2 →	+0.096	+4.039	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR10A7 by OR2L8 expression — SCLC

Explore this box plot interactively →