OR2L8

Across TCGA cell cohorts, OR2L8 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OR2L8-associated genes across cancer lineages are C5orf52, SPATA48, and GPR101. Each is linked with OR2L8 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2L8-to-partner and partner-to-OR2L8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by OR2L8-low versus OR2L8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2L8→partner) and Y-score (partner→OR2L8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C5orf52 →	+0.030	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	SPATA48 →	+0.007	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	GPR101 →	+0.017	+4.472	<.001	.001	3	1
LUNG_NSCLC_LUAD	GPR33 →	+0.012	+4.189	.001	.002	3	1
LUNG_NSCLC_LUAD	PIRT →	+0.005	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR1D4 →	+0.046	+5.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C5orf52 by OR2L8 expression — SKIN

Explore this box plot interactively →