Across TCGA pan-cancer cohorts, OR2L2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of OR2L2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OR2L2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR2L2 is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

HNSC, BRCA, and COAD are the cancer types where OR2L2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR2L2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.210	.002	7	view →
BRCA	All	All	−0.050	.002	6	view →
COAD	All	II,III,IV	−0.015	.011	4	view →
UCEC	All	All	−0.070	.012	2	view →
KICH	All	All	−0.020	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: OR2L2 RNA expression & survival · all OR2L2 data types