OR2I1P

Across TCGA pan-cancer cohorts, OR2I1P RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of OR2I1P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OR2I1P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR2I1P is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where OR2I1P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR2I1P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+3.483	<.001	12	view →
COAD	Female	II,III,IV	+2.192	<.001	10	view →
LIHC	Female	III,IV	+4.178	<.001	9	view →
STAD	All	II,III,IV	+2.944	<.001	8	view →
HNSC	All	All	+1.062	.006	4	view →
BRCA	All	All	+0.579	.004	4	view →
CHOL	Female	All	+6.970	<.001	3	view →
ESCA	All	All	+3.173	.003	3	view →
KICH	Female	II,III,IV	−1.704	.033	3	view →
READ	All	All	+2.385	.002	2	view →
BLCA	Male	All	+1.372	.026	2	view →
THCA	All	All	−0.845	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

OR2I1P–KIRC

Open the KIRC breakdown →