OR2G3

Across TCGA patient cohorts, OR2G3 mutation is significantly associated with the RNA expression of many other genes, with 1,748 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2G3-associated genes across cancer lineages are TKT, ITGAE, and GTF2H1. Each is linked with OR2G3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR2G3-to-partner and partner-to-OR2G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TKT grouped by OR2G3-low versus OR2G3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2G3→partner) and Y-score (partner→OR2G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TKT →	+0.686	+2.906	.001	.002	3	3
UCEC	ITGAE →	+0.540	+2.716	<.001	.003	3	3
UCEC	GTF2H1 →	+0.446	+2.906	.004	.002	3	3
UCEC	PDS5A →	+0.521	+3.632	.006	.001	3	3
LUAD	UBXN2A →	+0.356	+2.933	<.001	<.001	3	3
LUAD	MAP2K4 →	+0.371	+3.953	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,748 associations by consensus.

TKT by OR2G3 expression — UCEC

Explore this box plot interactively →