OR2G3

Across TCGA patient cohorts, OR2G3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2G3-associated genes across cancer lineages are p38-MAPK, p62 Lck ligand, and p70-S6K. Each is linked with OR2G3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR2G3-to-partner and partner-to-OR2G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK grouped by OR2G3-low versus OR2G3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2G3→partner) and Y-score (partner→OR2G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p38-MAPK →	+0.154	+2.889	.020	.030	3	3
UCEC	p62 Lck ligand →	+0.456	+2.179	.003	.034	3	3
LUSC	p70-S6K →	+0.264	+1.883	.009	.031	3	2
UCEC	JNK_pT183_Y185 →	-0.214	-3.321	.008	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.798	+3.189	.005	.010	3	2
COAD	G6PD →	+0.258	+2.815	.013	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

p38-MAPK by OR2G3 expression — LUAD

Explore this box plot interactively →