OR2G3

Across TCGA cell cohorts, OR2G3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR2G3-associated genes across cancer lineages are HHATL, IL17B, and THRSP. Each is linked with OR2G3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2G3-to-partner and partner-to-OR2G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHATL grouped by OR2G3-low versus OR2G3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2G3→partner) and Y-score (partner→OR2G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HHATL →	+0.088	+3.485	.001	.004	3	1
LUNG_NSCLC_LUAD	IL17B →	+0.260	+3.334	.004	.008	3	1
LUNG_NSCLC_LUAD	THRSP →	+0.084	+3.874	.003	.001	3	1
LUNG_NSCLC_LUAD	IQCF1 →	+0.100	+3.495	.005	.005	3	1
CNS	C1orf141 →	+0.012	+5.321	<.001	.005	3	1
LARGE_INTESTINE	MSGN1 →	+0.056	+3.345	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

HHATL by OR2G3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →