OR2G2

Across TCGA pan-cancer cohorts, OR2G2 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated OR2G2 data layer compared with 5 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher OR2G2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR2G2 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

SKCM, COAD, and STAD are the cancer types where OR2G2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	III,IV	0.360	0.718	<.001	90	view →
COAD	OS	Tertile	III,IV	0.203	0.793	<.001	63	view →
STAD	DFS	Tertile	All	0.502	0.739	.011	36	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
ESCA	OS	Tertile	III,IV	0.739	0.339	.003	36	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
LIHC	OS	Tertile	II,III,IV	0.128	0.617	.037	18	view →
PCPG	DFS	Tertile	All	0.105	0.828	<.001	18	view →
GBM	DFS	Tertile	All	0.112	0.260	.045	9	view →
HNSC	OS	Tertile	II,III,IV	0.645	0.339	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

OR2G2–SKCM (OS)

Open the SKCM breakdown →