Across TCGA pan-cancer cohorts, OR2F2 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of OR2F2’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where OR2F2 RNA is repressed in tumor relative to normal tissue. In most cancer types OR2F2 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
ESCA are the cancer types where OR2F2 tumor–normal differential expression is most reproducible.