Across TCGA patient cohorts, OR2C3 mutation is significantly associated with the RNA expression of many other genes, with 5,177 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2C3-associated genes across cancer lineages are MTMR4, ORC2, and MCM8. Each is linked with OR2C3 in more than 3 cancer types. Because this analysis shows association rather than direction, both OR2C3-to-partner and partner-to-OR2C3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2C3→partner) and Y-score (partner→OR2C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTMR4 →	+0.438	+1.938	.001	.001	3	4
LUAD	ORC2 →	+0.324	+2.485	.001	.001	3	4
LUSC	MCM8 →	+0.614	+2.807	<.001	.003	3	4
LUAD	METTL21A →	+0.330	+3.620	.001	.001	3	4
LUAD	KIF18B →	+0.852	+3.471	<.001	.002	3	4
UCEC	BUB1B →	+0.783	+2.654	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,177 associations by consensus.

Exploration

OR2C3 survival (RNA) · tumor vs normal (RNA) · all OR2C3 data types