OR2AE1

Across TCGA patient cohorts, OR2AE1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR2AE1-associated genes across cancer lineages are TFRC, MEK1, and p62 Lck ligand. Each is linked with OR2AE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2AE1-to-partner and partner-to-OR2AE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by OR2AE1-low versus OR2AE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2AE1→partner) and Y-score (partner→OR2AE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.686	+2.999	.005	.035	3	2
UCEC	MEK1 →	+0.551	+3.459	.001	.005	3	1
UCEC	p62 Lck ligand →	+0.374	+2.584	.013	.011	3	1
UCEC	PDK1_pS241 →	+0.166	+1.887	.037	.031	3	1
UCEC	Annexin-1 →	+0.666	+2.341	.006	.019	3	1
UCEC	Bax →	+0.252	+3.009	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TFRC by OR2AE1 expression — UCEC

Explore this box plot interactively →