Across TCGA pan-cancer cohorts, OR2A14 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR2A14’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where OR2A14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR2A14 is over-expressed in tumor.
BLCA and HNSC are the cancer types where OR2A14 tumor–normal differential expression is most reproducible.