Across TCGA cell cohorts, OR1S2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR1S2-associated genes across cancer lineages are DEFA3, DEFA4, and BPIFA1. Each is linked with OR1S2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1S2-to-partner and partner-to-OR1S2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1S2→partner) and Y-score (partner→OR1S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA3 →	+0.076	+4.415	<.001	.007	3	2
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1
LARGE_INTESTINE	BPIFA1 →	+0.205	+4.273	<.001	.006	3	1
LARGE_INTESTINE	PATE4 →	+0.046	+4.095	<.001	.009	3	1
LUNG_NSCLC_LUAD	OCM2 →	+0.033	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR52N1 →	+0.066	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

OR1S2 survival (RNA) · tumor vs normal (RNA) · all OR1S2 data types