OR1S1

Across TCGA cell cohorts, OR1S1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible OR1S1-associated genes across cancer lineages are RTL3, TECTB, and OR10G3. Each is linked with OR1S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1S1-to-partner and partner-to-OR1S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTL3 grouped by OR1S1-low versus OR1S1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1S1→partner) and Y-score (partner→OR1S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RTL3 →	+0.013	+2.669	.009	.004	3	1
PANCREAS	TECTB →	+0.983	+4.011	<.001	.009	3	1
LUNG_SCLC	OR10G3 →	+0.063	+5.643	<.001	.002	3	1
LUNG_SCLC	SPATA31D1 →	+0.843	+5.643	<.001	.002	3	1
LUNG_SCLC	TEX50 →	+0.040	+5.643	<.001	.002	3	1
LUNG_SCLC	SERPINA2 →	+0.038	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

RTL3 by OR1S1 expression — LARGE_INTESTINE

Explore this box plot interactively →