OR1L4

Across TCGA patient cohorts, OR1L4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1L4-associated genes across cancer lineages are AR, Acetyl-a-Tubulin-Lys40, and JNK2. Each is linked with OR1L4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1L4-to-partner and partner-to-OR1L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AR grouped by OR1L4-low versus OR1L4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1L4→partner) and Y-score (partner→OR1L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AR →	-0.198	-3.000	.018	.035	3	1
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.627	+3.169	.036	.019	2	1
UCEC	JNK2 →	+0.505	+3.009	<.001	.019	2	1
UCEC	VEGFR2 →	+0.425	+3.183	.009	.010	2	1
UCEC	Caspase-8 →	-0.342	-3.169	.013	.019	2	1
UCEC	CD49b →	-0.379	-3.156	.015	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

AR by OR1L4 expression — SKCM

Explore this box plot interactively →