OR1L4

Across TCGA cell cohorts, OR1L4 mutation is significantly associated with the mutation status of many other genes, with 2,099 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR1L4-associated genes across cancer lineages are HTR1B, UGGT2, and HPS5. Each is linked with OR1L4 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR1L4-to-partner and partner-to-OR1L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR1B grouped by OR1L4-low versus OR1L4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1L4→partner) and Y-score (partner→OR1L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HTR1B →	+4.392	+4.392	.009	.009	1	3
SKIN	UGGT2 →	+3.392	+4.718	.002	.002	1	3
SKIN	HPS5 →	+4.392	+4.392	.009	.009	1	3
BLOOD_Lymphoma	DPYSL3 →	+4.584	+4.584	.007	.007	1	3
SKIN	SLF2 →	+5.392	+4.824	.004	.004	1	3
SKIN	SH2D3A →	+4.392	+4.392	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,099 associations by consensus.

HTR1B by OR1L4 expression — SKIN

Explore this box plot interactively →