OR1L1

Across TCGA patient cohorts, OR1L1 mutation is significantly associated with the RNA expression of many other genes, with 2,996 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1L1-associated genes across cancer lineages are UHRF1, INCENP, and CPSF7. Each is linked with OR1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1L1-to-partner and partner-to-OR1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by OR1L1-low versus OR1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1L1→partner) and Y-score (partner→OR1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+1.158	+3.584	<.001	.002	3	2
UCEC	INCENP →	+0.825	+3.467	.001	.002	3	2
UCEC	CPSF7 →	+0.560	+3.839	<.001	<.001	3	2
UCEC	CHEK1 →	+0.957	+3.343	<.001	.005	3	2
UCEC	SCLT1 →	+0.475	+2.743	.003	.003	3	2
UCEC	CENPU →	+0.875	+3.212	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,996 associations by consensus.

UHRF1 by OR1L1 expression — UCEC

Explore this box plot interactively →