OR1L1

Across TCGA cell cohorts, OR1L1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OR1L1-associated genes across cancer lineages are H2BW1, HTR1A, and RBMY1B. Each is linked with OR1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1L1-to-partner and partner-to-OR1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW1 grouped by OR1L1-low versus OR1L1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1L1→partner) and Y-score (partner→OR1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	H2BW1 →	+0.183	+4.977	<.001	.007	3	1
SKIN	HTR1A →	+0.006	+5.415	<.001	.004	3	1
SKIN	RBMY1B →	+1.640	+4.977	<.001	.007	3	1
STOMACH	CYP11B2 →	+0.006	+5.285	<.001	.003	3	1
LARGE_INTESTINE	ENTHD1 →	+0.032	+4.139	.004	.007	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

H2BW1 by OR1L1 expression — SKIN

Explore this box plot interactively →