OR1K1

Across TCGA cell cohorts, OR1K1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,023 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OR1K1-associated GO terms across cancer lineages are Negative regulation of RNA splicing, Negative regulation of mRNA splicing, via spliceosome, and Regulation of glucose mediated signaling pathway. Each is linked with OR1K1 in more than 6 cancer types. Because this analysis shows association rather than direction, both OR1K1-to-partner and partner-to-OR1K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA splicing grouped by OR1K1-low versus OR1K1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1K1→partner) and Y-score (partner→OR1K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of RNA splicing →	+0.083	+0.029	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.091	+0.028	.001	.002	3	7
STOMACH	Regulation of glucose mediated signaling pathway →	+0.065	+0.031	.003	.004	3	6
STOMACH	Positive regulation of glucose mediated signaling pathway →	+0.065	+0.031	.003	.004	3	6
STOMACH	Negative regulation of calcium ion export across plasma membrane →	+0.061	+0.032	<.001	.002	3	6
BONE	Spindle localization →	+0.096	+0.020	.002	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,023 associations by consensus.

Negative regulation of RNA splicing by OR1K1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →