OR1J1

Across TCGA pan-cancer cohorts, OR1J1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of OR1J1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OR1J1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR1J1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

HNSC, LUSC, and BRCA are the cancer types where OR1J1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR1J1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.080	<.001	8	view →
LUSC	All	All	+0.150	<.001	7	view →
BRCA	All	II,III,IV	+0.067	.007	6	view →
LIHC	All	All	+0.049	.001	5	view →
LUAD	All	All	+0.054	.016	4	view →
COAD	All	All	+0.114	.015	2	view →
COAD	Female	IV	−0.090	.046	1	view →
THCA	Male	All	+0.028	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 7 lineages.

OR1J1–HNSC

Open the HNSC breakdown →