OR1D5

Across TCGA patient cohorts, OR1D5 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1D5-associated genes across cancer lineages are FOXO3a_pS318_S321, Ku80, and PKC-b-II_pS660. Each is linked with OR1D5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1D5-to-partner and partner-to-OR1D5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by OR1D5-low versus OR1D5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1D5→partner) and Y-score (partner→OR1D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.182	-3.160	.008	.019	3	1
UCEC	Ku80 →	+0.286	+3.183	.027	.010	3	1
UCEC	PKC-b-II_pS660 →	-0.528	-3.169	<.001	.019	3	1
UCEC	Rictor_pT1135 →	-0.118	-3.000	.035	.036	3	1
UCEC	STAT3_pY705 →	-0.545	-3.169	<.001	.020	3	1
UCEC	AR →	-0.483	-3.169	.018	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FOXO3a_pS318_S321 by OR1D5 expression — UCEC

Explore this box plot interactively →