Across TCGA patient cohorts, OR1C1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1C1-associated genes across cancer lineages are PCNA, FoxM1, and 4E-BP1_pS65. Each is linked with OR1C1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR1C1-to-partner and partner-to-OR1C1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1C1→partner) and Y-score (partner→OR1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.288	+2.906	.001	.001	3	3
LUAD	FoxM1 →	+0.295	+2.906	.004	.001	3	2
LUAD	4E-BP1_pS65 →	+0.161	+2.906	.004	.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.164	-2.690	.001	.006	3	2
SKCM	Ku80 →	+0.275	+2.459	.010	.017	3	2
UCEC	Rab25 →	-0.426	-3.169	.002	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

OR1C1 survival (RNA) · tumor vs normal (RNA) · all OR1C1 data types