OR1A2

Across TCGA patient cohorts, OR1A2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1A2-associated genes across cancer lineages are mTOR_pS2448, p70-S6K, and Rab25. Each is linked with OR1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1A2-to-partner and partner-to-OR1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by OR1A2-low versus OR1A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1A2→partner) and Y-score (partner→OR1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.153	-3.150	.027	.019	3	1
UCEC	p70-S6K →	+0.229	+2.611	.010	.006	3	1
UCEC	Rab25 →	-0.396	-3.000	.010	.036	3	1
UCEC	Src_pY416 →	-0.283	-2.571	.011	.011	3	1
UCEC	STAT3_pY705 →	-0.604	-3.700	<.001	.001	3	1
UCEC	VHL →	-0.853	-2.999	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

mTOR_pS2448 by OR1A2 expression — UCEC

Explore this box plot interactively →