OR1A2

Across TCGA cell cohorts, OR1A2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR1A2-associated genes across cancer lineages are KRTAP10-3, LIPK, and RASGEF1C. Each is linked with OR1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1A2-to-partner and partner-to-OR1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-3 grouped by OR1A2-low versus OR1A2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1A2→partner) and Y-score (partner→OR1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP10-3 →	+0.030	+5.977	<.001	.001	3	2
SOFT_TISSUE	LIPK →	+0.022	+4.930	<.001	.008	3	1
LARGE_INTESTINE	RASGEF1C →	+0.232	+3.404	.003	.006	3	1
LARGE_INTESTINE	MSGN1 →	+0.080	+3.760	<.001	<.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.239	+3.103	.001	.004	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.050	+2.994	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

KRTAP10-3 by OR1A2 expression — SOFT_TISSUE

Explore this box plot interactively →