OR13C5

Across TCGA patient cohorts, OR13C5 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR13C5-associated genes across cancer lineages are PDK1_pS241, STAT3_pY705, and AMPK_alpha. Each is linked with OR13C5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR13C5-to-partner and partner-to-OR13C5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by OR13C5-low versus OR13C5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR13C5→partner) and Y-score (partner→OR13C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.204	+2.183	.022	.035	3	1
UCEC	STAT3_pY705 →	-0.400	-2.999	.003	.035	3	1
SKCM	AMPK_alpha →	+0.105	+1.765	.045	.013	3	1
UCEC	Annexin-1 →	+0.665	+2.827	.015	.035	2	1
UCEC	MEK1 →	+0.608	+3.321	.001	.010	1	1
UCEC	Notch1 →	+0.269	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PDK1_pS241 by OR13C5 expression — UCEC

Explore this box plot interactively →