Across TCGA pan-cancer cohorts, OR12D3 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of OR12D3’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where OR12D3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types OR12D3 is over-expressed in tumor.
LUAD are the cancer types where OR12D3 tumor–normal differential expression is most reproducible.