OR11H4

Across TCGA patient cohorts, OR11H4 mutation is significantly associated with the RNA expression of many other genes, with 1,549 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR11H4-associated genes across cancer lineages are C18orf54, KDM5C-IT1, and GINS1. Each is linked with OR11H4 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR11H4-to-partner and partner-to-OR11H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf54 grouped by OR11H4-low versus OR11H4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR11H4→partner) and Y-score (partner→OR11H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C18orf54 →	+1.059	+3.470	<.001	.002	3	3
SKCM	KDM5C-IT1 →	+0.089	+2.853	.001	.001	3	2
UCEC	GINS1 →	+0.930	+3.606	.001	.001	3	2
UCEC	NCAPD2 →	+0.935	+3.470	<.001	.002	3	2
UCEC	CMC2 →	+0.682	+3.617	<.001	.001	3	2
UCEC	UBE2I →	+0.546	+3.606	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,549 associations by consensus.

C18orf54 by OR11H4 expression — UCEC

Explore this box plot interactively →