OR11H4

Across TCGA patient cohorts, OR11H4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR11H4-associated genes across cancer lineages are 4E-BP1, EGFR_pY1173, and JNK2. Each is linked with OR11H4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR11H4-to-partner and partner-to-OR11H4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by OR11H4-low versus OR11H4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR11H4→partner) and Y-score (partner→OR11H4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.446	+2.837	.001	.035	3	2
UCEC	EGFR_pY1173 →	+0.086	+2.196	.039	.034	3	1
UCEC	JNK2 →	+0.311	+2.834	.002	.034	3	1
UCEC	Ku80 →	+0.247	+2.183	.046	.035	3	1
UCEC	PKC-b-II_pS660 →	-0.497	-3.169	<.001	.019	3	1
UCEC	Rab25 →	-0.614	-3.000	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

4E-BP1 by OR11H4 expression — UCEC

Explore this box plot interactively →