OR11H1

Across TCGA patient cohorts, OR11H1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR11H1-associated genes across cancer lineages are PCNA, FoxM1, and ACC1. Each is linked with OR11H1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR11H1-to-partner and partner-to-OR11H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by OR11H1-low versus OR11H1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR11H1→partner) and Y-score (partner→OR11H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.262	+3.321	.007	.010	3	3
UCEC	FoxM1 →	+0.330	+2.700	.004	.006	3	2
UCEC	ACC1 →	+0.331	+2.820	.043	.035	3	2
UCEC	MEK1 →	+0.393	+3.459	.017	.005	3	2
UCEC	Tuberin →	+0.491	+2.594	<.001	.006	3	2
UCEC	ATM →	-0.617	-2.700	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PCNA by OR11H1 expression — UCEC

Explore this box plot interactively →