Across TCGA pan-cancer cohorts, OR10S1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OR10S1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OR10S1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR10S1 is over-expressed in tumor.
HNSC, KICH, and LUSC are the cancer types where OR10S1 tumor–normal differential expression is most reproducible.