OR10G3

Across TCGA patient cohorts, OR10G3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR10G3-associated genes across cancer lineages are ERK2, MSH2, and MSH6. Each is linked with OR10G3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR10G3-to-partner and partner-to-OR10G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by OR10G3-low versus OR10G3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR10G3→partner) and Y-score (partner→OR10G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.204	+3.169	.023	.019	3	1
UCEC	MSH2 →	-0.323	-3.143	.002	.018	3	1
UCEC	MSH6 →	-0.496	-3.169	.001	.018	3	1
UCEC	p90 RSK →	+0.189	+1.887	.034	.031	3	1
UCEC	PCNA →	+0.237	+2.999	.018	.035	3	1
UCEC	Annexin-1 →	+0.788	+2.584	.001	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ERK2 by OR10G3 expression — UCEC

Explore this box plot interactively →