OR10G2

Across TCGA patient cohorts, OR10G2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR10G2-associated genes across cancer lineages are N-Cadherin, Src_pY527, and eIF4G. Each is linked with OR10G2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR10G2-to-partner and partner-to-OR10G2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Cadherin grouped by OR10G2-low versus OR10G2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR10G2→partner) and Y-score (partner→OR10G2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	N-Cadherin →	+0.184	+1.700	.025	.043	3	2
UCEC	Src_pY527 →	-0.444	-2.990	.032	.036	3	2
UCEC	eIF4G →	+0.407	+2.459	.006	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.191	-2.446	.019	.020	3	1
UCEC	p21 →	+0.209	+2.459	.024	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.607	-2.999	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

N-Cadherin by OR10G2 expression — SKCM

Explore this box plot interactively →