Across TCGA pan-cancer cohorts, OR10AD1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OR10AD1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OR10AD1 RNA is repressed in tumor relative to normal tissue. In most cancer types OR10AD1 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.
KIRC, BRCA, and LUAD are the cancer types where OR10AD1 tumor–normal differential expression is most reproducible.