OR10A5

Across TCGA patient cohorts, OR10A5 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR10A5-associated genes across cancer lineages are ASNS, Cyclin-B1, and EGFR_pY1068. Each is linked with OR10A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR10A5-to-partner and partner-to-OR10A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by OR10A5-low versus OR10A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR10A5→partner) and Y-score (partner→OR10A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.452	+3.321	.003	.010	3	2
UCEC	Cyclin-B1 →	+0.560	+2.222	.018	.011	3	2
UCEC	EGFR_pY1068 →	-0.221	-1.700	.038	.044	3	1
UCEC	JNK2 →	+0.190	+3.026	.024	.018	3	1
UCEC	MEK1 →	+0.409	+3.584	.008	.002	3	1
UCEC	Notch1 →	+0.202	+3.710	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ASNS by OR10A5 expression — UCEC

Explore this box plot interactively →