OR10A4

Across TCGA patient cohorts, OR10A4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR10A4-associated genes across cancer lineages are A-Raf_pS299, p62 Lck ligand, and Annexin-1. Each is linked with OR10A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR10A4-to-partner and partner-to-OR10A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by OR10A4-low versus OR10A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR10A4→partner) and Y-score (partner→OR10A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.228	-3.321	<.001	.010	3	1
UCEC	p62 Lck ligand →	+0.454	+3.009	.007	.019	3	1
UCEC	Annexin-1 →	+0.986	+3.189	<.001	.010	3	1
UCEC	TIGAR →	+0.177	+2.196	.026	.034	3	1
UCEC	ASNS →	+0.577	+3.000	.002	.036	3	1
UCEC	Cyclin-B1 →	+0.816	+2.999	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

A-Raf_pS299 by OR10A4 expression — UCEC

Explore this box plot interactively →