OPTN

Across TCGA pan-cancer cohorts, OPTN mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated OPTN data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher OPTN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OPTN expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

COAD, LSCC, and PDAC are the cancer types where OPTN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.822	1.000	.023	66	view →
LSCC	DFS	Tertile	II,III,IV	0.498	0.956	<.001	46	view →
PDAC	OS	Quartile	All	0.612	0.358	.006	22	view →
LUAD	DFS	Median	All	0.952	0.882	.008	15	view →
HNSC	OS	Median	All	0.795	0.623	.009	10	view →
CCRCC	DFS	Median	III,IV	0.774	0.207	.047	2	view →
UCEC	DFS	Tertile	II,III,IV	0.761	1.000	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OPTN–COAD (DFS)

Open the COAD breakdown →