OPTN

Across TCGA patient cohorts, OPTN RNA expression is significantly associated with the protein abundance of many other proteins, with 17,571 significant associations in total. GBM shows the largest number of these associations.

The most reproducible OPTN-associated proteins across cancer lineages are PFKP, IFIT3, and OPTN_S198. Each is linked with OPTN in more than 6 cancer types. Because this analysis shows association rather than direction, both OPTN-to-partner and partner-to-OPTN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OPTN versus PFKP in BRCA, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (OPTN→partner) and Y-score (partner→OPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PFKP →	+0.580	+0.580	<.001	<.001	3	7
OV	IFIT3 →	+0.704	+0.755	.001	.001	3	6
PDAC	OPTN_S198 →	+1.035	+0.434	.007	.001	2	7
HNSC	TRIM21 →	+0.564	+0.699	<.001	<.001	2	6
OV	TYMP →	+0.656	+0.901	<.001	<.001	3	5
COAD	XAF1 →	+0.847	+0.505	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,571 associations by consensus.

OPTN vs PFKP — BRCA

Explore this scatter interactively →