OPTN

Across TCGA patient cohorts, OPTN mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPTN-associated genes across cancer lineages are Rb_pS807_S811, Smad4, and c-Met_pY1235. Each is linked with OPTN in more than 1 cancer types. Because this analysis shows association rather than direction, both OPTN-to-partner and partner-to-OPTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rb_pS807_S811 grouped by OPTN-low versus OPTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPTN→partner) and Y-score (partner→OPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rb_pS807_S811 →	-0.364	-1.700	.034	.044	3	2
UCEC	Smad4 →	+0.113	+2.999	.028	.035	3	2
UCEC	c-Met_pY1235 →	+0.074	+2.179	.018	.034	3	2
UCEC	GSK-3_pS9 →	-0.358	-1.700	.037	.044	3	1
UCEC	p62 Lck ligand →	+0.389	+3.594	.004	.001	3	1
UCEC	PCNA →	+0.359	+2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Rb_pS807_S811 by OPTN expression — UCEC

Explore this box plot interactively →