OPTN

Across TCGA cell cohorts, OPTN RNA expression is significantly associated with the go_rna of many other GO terms, with 6,830 significant associations in total. BONE shows the largest number of these associations.

The most reproducible OPTN-associated GO terms across cancer lineages are Golgi ribbon formation, Negative regulation of extrinsic apoptotic signaling pathway, and Type 2 mitophagy. Each is linked with OPTN in more than 15 cancer types. Because this analysis shows association rather than direction, both OPTN-to-partner and partner-to-OPTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi ribbon formation grouped by OPTN-low versus OPTN-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OPTN→partner) and Y-score (partner→OPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Golgi ribbon formation →	+0.136	+2.543	<.001	<.001	3	16
BONE	Negative regulation of extrinsic apoptotic signaling pathway →	+0.107	+1.779	<.001	<.001	3	16
OESOPHAGUS	Type 2 mitophagy →	+0.277	+2.023	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Canonical NF-kappaB signal transduction →	+0.141	+2.337	<.001	<.001	3	15
BONE	Apoptotic signaling pathway →	+0.073	+2.862	<.001	<.001	3	15
BONE	Regulation of extrinsic apoptotic signaling pathway →	+0.088	+1.765	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,830 associations by consensus.

Golgi ribbon formation by OPTN expression — BREAST

Explore this box plot interactively →