OPTN

Across TCGA cell cohorts, OPTN mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OPTN-associated genes across cancer lineages are ELOVL3, BMP10, and NRTN. Each is linked with OPTN in more than 1 cancer types. Because this analysis shows association rather than direction, both OPTN-to-partner and partner-to-OPTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOVL3 grouped by OPTN-low versus OPTN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPTN→partner) and Y-score (partner→OPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOVL3 →	+1.054	+3.064	<.001	.009	3	1
LARGE_INTESTINE	BMP10 →	+0.016	+2.560	<.001	.008	3	1
LARGE_INTESTINE	NRTN →	+0.998	+3.064	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.027	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	LCE2C →	+0.031	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	C1orf146 →	+0.025	+4.734	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ELOVL3 by OPTN expression — LARGE_INTESTINE

Explore this box plot interactively →