OPRM1

Across TCGA patient cohorts, OPRM1 mutation is significantly associated with the RNA expression of many other genes, with 3,061 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPRM1-associated genes across cancer lineages are SLC25A33, MCM10, and SLC19A3. Each is linked with OPRM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both OPRM1-to-partner and partner-to-OPRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A33 grouped by OPRM1-low versus OPRM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRM1→partner) and Y-score (partner→OPRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A33 →	+0.484	+1.660	<.001	.003	3	3
COAD	MCM10 →	+0.609	+2.937	<.001	<.001	3	3
COAD	SLC19A3 →	-0.865	-2.087	.002	.005	2	4
UCEC	C4orf46 →	+0.520	+2.031	<.001	.004	3	3
UCEC	RNU6-33P →	+0.359	+1.523	.002	.003	3	3
UCEC	CYB5RL →	+0.311	+2.370	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,061 associations by consensus.

SLC25A33 by OPRM1 expression — UCEC

Explore this box plot interactively →