OPRM1

Across TCGA cell cohorts, OPRM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 270 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible OPRM1-associated GO terms across cancer lineages are Cell-substrate junction assembly, Regulation of type I interferon-mediated signaling pathway, and Protein stabilization. Each is linked with OPRM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both OPRM1-to-partner and partner-to-OPRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-substrate junction assembly grouped by OPRM1-low versus OPRM1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRM1→partner) and Y-score (partner→OPRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cell-substrate junction assembly →	+0.107	+0.037	.003	.008	3	5
PANCREAS	Regulation of type I interferon-mediated signaling pathway →	+0.073	+0.050	.002	.005	3	4
UPPER_AERODIGESTIVE_TRACT	Protein stabilization →	+0.052	+0.082	.001	.007	2	4
LUNG_NSCLC_LUSC	Cellular response to aldehyde →	+0.113	+0.113	.002	.009	3	3
LUNG_NSCLC_LUSC	Peptidyl-serine phosphorylation →	+0.054	+0.126	.004	.003	3	3
LUNG_NSCLC_LUSC	Regulation of protein lipidation →	+0.151	+0.205	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 270 associations by consensus.

Cell-substrate junction assembly by OPRM1 expression — PANCREAS

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